Motif ID: MEF2{A,B,C,D}.p2

Z-value: 1.211


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D



Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_79625538 3.260 NM_002469
MYF6
myogenic factor 6 (herculin)
chr5_+_155686333 3.246 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr10_+_50177192 3.057 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr10_+_69539255 3.053 NM_032578
MYPN
myopalladin
chr2_-_190635566 2.984 NM_005259
MSTN
myostatin
chr10_-_75085754 2.960 NM_001114133
SYNPO2L
synaptopodin 2-like
chr3_-_39209075 2.953 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr2_+_88148413 2.814 NM_198274
SMYD1
SET and MYND domain containing 1
chr10_-_75080784 2.655 NM_024875
SYNPO2L
synaptopodin 2-like
chr8_+_67201684 2.623 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr2_+_170074457 2.586 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr16_+_31132842 2.520 NM_001008274
TRIM72
tripartite motif containing 72
chr5_+_53787187 2.386 NM_006308
HSPB3
heat shock 27kDa protein 3
chr1_-_199657468 2.359 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr10_+_111755715 2.301 NM_019903
ADD3
adducin 3 (gamma)
chrX_-_21686079 2.115 NM_014332
SMPX
small muscle protein, X-linked
chr2_+_238712101 2.108 NM_198582
KLHL30
kelch-like 30 (Drosophila)
chr1_-_199613406 2.106 TNNT2
troponin T type 2 (cardiac)
chr4_+_169654742 2.050 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr22_+_24468168 2.034 MYO18B
myosin XVIIIB
chr1_-_199613427 2.027 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr7_+_93862137 1.926 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr12_-_55931172 1.875 NM_145064
STAC3
SH3 and cysteine rich domain 3
chr22_+_24468110 1.835 NM_032608
MYO18B
myosin XVIIIB
chr1_-_151784889 1.799 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr16_+_14187965 1.712 MKL2
MKL/myocardin-like 2
chr11_-_85107569 1.691 NM_206929
SYTL2
synaptotagmin-like 2
chr3_+_8750485 1.580 NM_033337
NM_001234
CAV3

caveolin 3

chr17_+_42641712 1.476 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr2_-_210876560 1.472 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr18_-_3209986 1.412 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr2_-_105421661 1.412 NM_201557
FHL2
four and a half LIM domains 2
chr3_+_35658852 1.400 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_+_35696119 1.389 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr7_+_154943466 1.336 NM_001427
EN2
engrailed homeobox 2
chr1_+_144124547 1.336 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr5_-_111119846 1.334 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr2_-_179623030 1.206 NM_173648
CCDC141
coiled-coil domain containing 141
chr7_+_18501876 1.170 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr20_+_19903778 1.168 RIN2
Ras and Rab interactor 2
chrX_-_142549984 1.130 NM_001184750
SLITRK4
SLIT and NTRK-like family, member 4
chr18_-_3209846 1.118 MYOM1
myomesin 1, 185kDa
chr17_-_24491521 1.115 MYO18A
myosin XVIIIA
chr12_+_118100977 1.085 NM_014365
HSPB8
heat shock 22kDa protein 8
chr16_-_31347151 1.085 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr15_+_61676604 1.076 NM_203373
FBXL22
F-box and leucine-rich repeat protein 22
chr20_+_60558104 1.060 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr14_+_23670514 1.059 NM_203402
FITM1
fat storage-inducing transmembrane protein 1
chr3_-_115825742 1.035 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_21985433 1.034 ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr17_-_10500189 1.032 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chrX_+_152699616 1.022 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr1_-_154727014 1.021 MEF2D
myocyte enhancer factor 2D
chr19_+_23091616 1.021 ZNF730
zinc finger protein 730
chr17_+_42641426 1.016 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr8_-_72431274 1.007 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr7_-_113346284 0.956 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr6_-_76259976 0.952 NM_015687
FILIP1
filamin A interacting protein 1
chr6_-_130224108 0.950 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr11_-_62213577 0.934 LRRN4CL
LRRN4 C-terminal like
chr2_-_162808123 0.931 NM_004460
FAP
fibroblast activation protein, alpha
chr3_-_102194938 0.928 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr1_-_16217025 0.905 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr10_+_88418243 0.880 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr1_+_201364050 0.872 ADORA1
adenosine A1 receptor
chr11_-_19180092 0.868 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr7_+_18502342 0.861 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr3_+_129117007 0.859 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr12_-_109842736 0.848 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr9_+_115367122 0.848 NM_134427
RGS3
regulator of G-protein signaling 3
chr4_-_177427252 0.842 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr6_+_42896771 0.832 NM_015349
KIAA0240
KIAA0240
chr1_+_154478574 0.831 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr6_-_139654807 0.825 NM_153235
TXLNB
taxilin beta
chr1_-_26266571 0.824 NM_032588
TRIM63
tripartite motif containing 63
chr10_-_69095362 0.823 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_242283129 0.815 NM_006352
ZNF238
zinc finger protein 238
chr15_-_68781662 0.814 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_+_30917939 0.813 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr17_-_77474597 0.807 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr2_+_233099113 0.793 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr1_-_100416358 0.785 NM_144620
LRRC39
leucine rich repeat containing 39
chr1_-_116112684 0.783 CASQ2
calsequestrin 2 (cardiac muscle)
chrX_-_138114100 0.771 FGF13
fibroblast growth factor 13
chrX_-_77801480 0.765 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr1_-_202595666 0.761 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr3_+_139550368 0.745 MRAS
muscle RAS oncogene homolog
chr10_+_80569464 0.744 ZMIZ1
zinc finger, MIZ-type containing 1
chr5_-_142057692 0.742 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr2_+_149603226 0.728 NM_177964
LYPD6B
LY6/PLAUR domain containing 6B
chr12_-_68379331 0.725 NM_032735
BEST3
bestrophin 3
chr16_+_82885821 0.720 NM_021197
WFDC1
WAP four-disulfide core domain 1
chr4_+_111053488 0.712 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr1_+_158352143 0.712 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_-_11585264 0.710 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chrX_-_138114846 0.708 NM_001139498
NM_001139500
NM_001139501
FGF13


fibroblast growth factor 13


chrX_-_142550535 0.691 NM_173078
SLITRK4
SLIT and NTRK-like family, member 4
chr12_-_242255 0.679 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr10_+_91082218 0.677 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_+_42702014 0.676 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr11_-_62213946 0.664 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr6_-_169395847 0.662 THBS2
thrombospondin 2
chr19_-_58086410 0.660 NM_207333
ZNF320
zinc finger protein 320
chr6_+_136214495 0.656 NM_018945
PDE7B
phosphodiesterase 7B
chr1_-_116112853 0.654 CASQ2
calsequestrin 2 (cardiac muscle)
chr17_-_31548167 0.649 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr8_-_122722674 0.649 NM_005328
HAS2
hyaluronan synthase 2
chr1_-_116112921 0.648 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr5_+_175041069 0.641 NM_022304
HRH2
histamine receptor H2
chr10_+_88418147 0.636 NM_001171610
LDB3
LIM domain binding 3
chr2_-_189752575 0.632 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_-_169395972 0.631 NM_003247
THBS2
thrombospondin 2
chr2_+_219991342 0.630 NM_001927
DES
desmin
chr19_+_19872700 0.627 NM_031218
ZNF93
zinc finger protein 93
chr4_+_114190233 0.627 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr9_-_135379888 0.625 NM_001080483
TMEM8C
transmembrane protein 8C
chr3_-_69254226 0.622 NM_198271
LMOD3
leiomodin 3 (fetal)
chr19_+_43847049 0.620


chrX_-_138114817 0.619 FGF13
fibroblast growth factor 13
chr16_-_29797172 0.616 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr4_-_1185144 0.615 LOC100130872
hypothetical LOC100130872
chr18_+_12397894 0.607 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr12_-_54522881 0.604 NM_002429
MMP19
matrix metallopeptidase 19
chr17_+_35075124 0.604 NM_003673
TCAP
titin-cap (telethonin)
chr1_+_144236398 0.603 ITGA10
integrin, alpha 10
chr19_-_55912006 0.602 NM_016148
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr14_-_103058568 0.598 CKB
creatine kinase, brain
chr3_-_48573556 0.590 PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr4_+_120276386 0.583 NM_016599
MYOZ2
myozenin 2
chr1_+_144236346 0.582 NM_003637
ITGA10
integrin, alpha 10
chr5_-_83052606 0.579 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr5_+_176494690 0.578 NSD1
nuclear receptor binding SET domain protein 1
chr17_-_43254117 0.575 OSBPL7
oxysterol binding protein-like 7
chr1_-_31618405 0.562 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr4_+_146820805 0.558 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr2_+_5750229 0.552 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr15_+_66695932 0.544 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr8_+_1980564 0.544 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr4_-_138673078 0.542 NM_019035
PCDH18
protocadherin 18
chr16_-_49205063 0.541


chr17_-_43254132 0.541 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr4_+_41057322 0.539 LIMCH1
LIM and calponin homology domains 1
chr3_-_139317140 0.539 NM_173543
DZIP1L
DAZ interacting protein 1-like
chr19_+_3884100 0.535 NM_170678
ITGB1BP3
integrin beta 1 binding protein 3
chr10_-_14412813 0.530 NM_018027
FRMD4A
FERM domain containing 4A
chr2_+_220007943 0.530 NM_005876
SPEG
SPEG complex locus
chr9_+_138991775 0.518 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr3_+_139550134 0.518 NM_001085049
MRAS
muscle RAS oncogene homolog
chr5_+_132037271 0.516 NM_000589
NM_172348
IL4

interleukin 4

chr9_-_99740243 0.512 NM_197978
HEMGN
hemogen
chr4_+_41057507 0.506 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr3_-_113842652 0.506 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr10_-_62373828 0.505 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr8_+_66744659 0.503 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr1_-_149611768 0.501 NM_003944
SELENBP1
selenium binding protein 1
chr10_+_5478521 0.499 NM_005863
NET1
neuroepithelial cell transforming 1
chr7_-_76667045 0.498 NM_006682
FGL2
fibrinogen-like 2
chr5_+_140532385 0.498 NM_018940
PCDHB7
protocadherin beta 7
chrX_-_11194015 0.497 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr17_+_1612056 0.496 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_-_91395194 0.493 NM_148977
PANK1
pantothenate kinase 1
chr6_-_165643064 0.492 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr3_+_185300660 0.490 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr10_-_121592020 0.485 MCMBP
minichromosome maintenance complex binding protein
chr10_+_86174665 0.483 FAM190B
family with sequence similarity 190, member B
chr4_+_41057600 0.483


chr3_-_193928038 0.478 NM_004113
FGF12
fibroblast growth factor 12
chr17_-_10265991 0.476 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr1_-_115039614 0.474 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr4_-_186934059 0.472 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr6_-_131333173 0.468 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr9_+_130056513 0.467


chr1_+_144183811 0.460 ANKRD34A
ankyrin repeat domain 34A
chr3_-_171070314 0.459 NM_024727
LRRC31
leucine rich repeat containing 31
chr5_+_244625 0.458 NM_001080478
LRRC14B
leucine rich repeat containing 14B
chr19_+_12064077 0.457 ZNF788
zinc finger family member 788
chr14_+_99309688 0.454 EML1
echinoderm microtubule associated protein like 1
chr19_-_2207415 0.454 NM_144616
JSRP1
junctional sarcoplasmic reticulum protein 1
chr5_+_140730014 0.452 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr11_+_46339691 0.448 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr2_-_217268492 0.442 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr17_-_26672757 0.441 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr10_-_95231933 0.439 NM_013451
NM_133337
MYOF

myoferlin

chr22_-_28972683 0.435 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr17_+_1612031 0.434 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_-_10362583 0.432 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr5_-_140875591 0.430 DIAPH1
diaphanous homolog 1 (Drosophila)
chr13_-_59223074 0.429


chr5_-_42847716 0.426 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr7_+_100037817 0.424 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr11_+_1897374 0.418 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr1_+_25629968 0.418 NM_018202
TMEM57
transmembrane protein 57
chr17_+_1611983 0.418 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chrX_+_70438352 0.417 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr1_-_156923111 0.417 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr3_+_50291521 0.416 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr12_+_52696908 0.416 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr5_+_121493113 0.412 NM_207317
ZNF474
zinc finger protein 474
chr1_-_24311212 0.411 NM_152372
MYOM3
myomesin family, member 3
chr7_+_110518297 0.405 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.62 6.65e-07 GO:0061061 muscle structure development
2.88 3.88e-06 GO:0007517 muscle organ development
2.77 7.95e-05 GO:0003012 muscle system process
2.31 2.17e-04 GO:0030029 actin filament-based process
4.77 3.01e-03 GO:0030049 muscle filament sliding
4.77 3.01e-03 GO:0033275 actin-myosin filament sliding
4.65 4.27e-03 GO:0070252 actin-mediated cell contraction
2.49 1.06e-02 GO:0006936 muscle contraction
3.73 3.19e-02 GO:0030048 actin filament-based movement
2.59 3.66e-02 GO:0042692 muscle cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.57 6.67e-14 GO:0030016 myofibril
4.31 6.29e-13 GO:0043292 contractile fiber
4.45 1.04e-12 GO:0044449 contractile fiber part
4.71 1.96e-12 GO:0030017 sarcomere
4.53 6.09e-05 GO:0031674 I band
4.65 6.28e-04 GO:0030018 Z disc

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.98 4.10e-03 GO:0003779 actin binding
1.71 9.25e-03 GO:0008092 cytoskeletal protein binding
3.79 2.52e-02 GO:0008307 structural constituent of muscle